I guess you mean Central America (the "bridge" between Mexico and South America), excluding the Caribbean islands.
If you only mean Central America, the poorest is Nicaragua, with a Human Development Index (HDI) of 0.699 (for comparison purposes, US and Canada's HDI values are 0.956 and 0.966, respectively).
If you include the Caribbean islands, Haiti (HDI = 0.532) is the poorest country in the Americas.
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