What are the disadvantages of cisplatin?

Cisplatin, while effective in treating various cancers, has notable disadvantages, including significant toxicity. Common side effects include nausea, vomiting, renal toxicity, and myelosuppression, which can lead to increased risk of infection and anemia. Additionally, some tumors may develop resistance to cisplatin over time, limiting its long-term efficacy. Lastly, it can cause ototoxicity, leading to hearing loss in some patients.