How many of the original settlers of the Plymouth colony died?

Of the original settlers of the Plymouth Colony, approximately half, or around 50 of the 102 passengers who arrived on the Mayflower, died during the first winter of 1620-1621. The harsh conditions, including cold weather, food shortages, and diseases, took a significant toll on the settlers. By the spring of 1621, only about 50 colonists remained alive.