Is Cubs manager Lou Piniella Hispanic?

yes

Piniella grew up in West Tampa, Florida. His Asturian grandparents immigrated to Florida from Asturias, Spain. As a child, he played PONY League Baseball alongside Tony La Russa. He attended Jesuit High School of Tampa where he was an All-American in Basketball. After graduation, he attended the University of Tampa where he was an All-American in baseball

The Asturians are an ethnic group or nation living in the historical country of the Principality of Asturias, provinces of León, Zamora, Santander and Tras OS Montes in the north of Spain and Portugal. They have Celtic and Visigothic background and they speak the Asturian language