How does THC cause dry mouth?

THC, the psychoactive compound in cannabis, causes dry mouth primarily by interacting with the endocannabinoid system, which regulates various physiological processes, including salivation. Specifically, THC binds to cannabinoid receptors in the salivary glands, inhibiting saliva production. This reduction in saliva leads to the sensation of dry mouth, or xerostomia, a common side effect experienced by cannabis users.