I was prescribed both methylprednisolone and vicodin by my doctor for a back injury. Therefore I'm assuming its safe (for me and my lack of pre-existing medical conditions at least) to take both. However, I wouldn't recommend it. The first day I took a 750mg vicodin on top of my methylprednisolone dosage, I was in bed for about 3 hours feeling like i was going to throw up. I personally tend to have that reaction to pain killers anyway though. NOT fun! I'd start with a half dose of vicodin first to see how you react.
newtest3
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