Nonsteroid hormones are synthesized from amino acids or lipids. Protein-based nonsteroid hormones, such as peptide hormones, are typically synthesized in the rough endoplasmic reticulum and processed in the Golgi apparatus. On the other hand, steroid hormones, which are lipid-derived, are synthesized from cholesterol in the smooth endoplasmic reticulum of steroidogenic cells. Ultimately, the specific precursor for each nonsteroid hormone depends on its chemical structure and function.
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