To change a tire on a 2001 Holden Vectra without a hub lock key, you'll need to use alternative methods to remove the wheel. One option is to carefully use a breaker bar and a socket that fits the lug nut, applying penetrating oil if necessary to loosen it. If the lug nuts have a unique shape and the above method fails, consider using a universal lug nut remover or a bolt extractor. Always ensure safety by securing the vehicle on a flat surface and using wheel chocks.
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