The major gland that triggers the onset of puberty is the hypothalamus. It releases gonadotropin-releasing hormone (GnRH), which signals the pituitary gland to produce hormones like luteinizing hormone (LH) and follicle-stimulating hormone (FSH). These hormones then stimulate the gonads (testes in males and ovaries in females) to produce sex hormones, leading to the physical and hormonal changes associated with puberty.
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