What are the rarest of WBCs that release histamine and exaggerate the inflammatory response?

The rarest type of white blood cells (WBCs) that release histamine and can exaggerate the inflammatory response are basophils. These cells account for less than 1% of the total WBC count and play a crucial role in allergic reactions and inflammatory responses by releasing histamine and other mediators. Their activation contributes significantly to the symptoms of Allergies and Asthma, enhancing vascular permeability and promoting inflammation.