Methotrexate in killing leukemia cells

Methotrexate is a chemotherapy agent that interferes with DNA synthesis by inhibiting the enzyme dihydrofolate reductase, which is crucial for the production of nucleotides necessary for cell division. In leukemia treatment, it targets rapidly dividing cancer cells, leading to their apoptosis. Methotrexate can be particularly effective in certain types of leukemia, such as acute lymphoblastic leukemia (ALL), where it helps to induce remission. However, its efficacy can vary based on the specific leukemia subtype and the individual patient's response to treatment.