What causes high ferritin and low iron?

High ferritin levels with low iron can indicate an underlying inflammation or chronic disease, as ferritin is an acute-phase reactant that increases in response to inflammation. Conditions such as infections, liver disease, or autoimmune disorders can cause this discrepancy. Additionally, iron sequestration can occur in chronic illnesses, where the body retains iron despite low serum iron levels. It's essential to consult a healthcare professional for accurate diagnosis and management.