What major events happened between 1492 - 1600?

Between 1492 and 1600, several significant events shaped history, most notably Christopher Columbus's voyage in 1492, which marked the beginning of European exploration and colonization of the Americas. The Protestant Reformation began in 1517, leading to major religious and political upheaval in Europe. The Spanish Armada was defeated in 1588, marking the decline of Spanish naval dominance. Additionally, the establishment of trade routes and colonies by various European powers significantly impacted global trade and indigenous populations.