How do you get from Charleston sc to mytle beach?

To get from Charleston, SC, to Myrtle Beach, you can take US-17 N, which is the most direct route. The drive typically takes about 2 to 2.5 hours, depending on traffic. Alternatively, you can take I-26 W to US-501 N for a similar travel time. Be sure to check traffic conditions before you go for the best route.