Is it possible to refill the enchantment on wuuthrad in skyrim?

Ah, isn't that a lovely question. In Skyrim, my friend, you can't refill the enchantment on Wuuthrad directly. However, you can disenchant it to learn the enchantment and then apply it to another weapon if you'd like. Remember, there are always creative ways to keep your adventures enchanted in the world of Skyrim. Happy painting!