Why nonionic surfactants are only used in niosome formulation?

Nonionic surfactants are preferred in niOSome formulations due to their low toxicity and biocompatibility, which make them suitable for drug delivery applications. They do not carry a charge, minimizing interactions with charged biological membranes and enhancing the stability of the niOSomes. Additionally, nonionic surfactants can form stable bilayers, allowing for better encapsulation of hydrophilic and lipophilic drugs, which is critical for effective therapeutic delivery.