Does Benadryl help with Oxycontin withdrawal?

It is never wise to mix drugs and medications, and it can cause serious side effects or even death. Oxycodone is a major drug that should never be mixed with any other medications without a doctor's supervision and approval. This is something that should be discussed with your doctor because while maybe someone else is ok after mixing these two drugs, it may not be okay for you. Everyone's bodies are different and their systems function in a wide range of abilities between person to person. Oxycodone is already a depressant on the nervous system. Benedryl is also a depressant on the nervous system. Depressant times two on the nervous system is likely to cause some sort of a failure from something as small as making you sleepy to something as major as shutting down brain functions that can't recover, and resulting in a coma or death.