Why did victor feel that his hands were thrice accursed?

Victor Frankenstein felt that his hands were "thrice accursed" because he recognized the immense guilt and responsibility he bore for creating the creature that ultimately led to the suffering and deaths of those he loved. His ambition to transcend natural boundaries resulted in catastrophic consequences, prompting him to view his actions as a betrayal of humanity and a violation of the natural order. This deep sense of remorse and Horror at the chaos he unleashed led him to regard his own hands, the instruments of his creation, as cursed.