Take the Downtown 6 local train (of the 4-5-6, the dark green line) from 42nd Street-Grand Central Station to Spring Street. Or, you can take the Downtown 4 or 5 trains (which are express) one stop, from Grand Central to 14th Street-Union Square, and transfer at Union Square to the Downtown 6 to Spring Street.
You will exit the subway on Spring Street, at Lafayette Street. Walk one block south to Broome Street, and 3 1/2 blocks west to 459 Broome Street between Greene and Mercer Streets.
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