What is huntingtons disease phenotype?

Huntington's disease phenotype is characterized by a progressive decline in motor control, cognitive function, and psychiatric health due to the degeneration of neurons in specific brain regions. Clinically, it manifests as chorea (involuntary movements), dystonia, and cognitive decline, often accompanied by mood disorders such as depression and anxiety. Symptoms typically begin in mid-adulthood and worsen over time, leading to significant disability and ultimately impacting life expectancy. Genetic testing can confirm the presence of mutations in the HTT gene, which are responsible for the disease.