What is the last thing alcohol affects?

Alcohol primarily affects the brain, where it impairs cognitive functions, coordination, and judgment. The last thing it typically affects is the body's autonomic functions, such as breathing and heart rate, which can become dangerously compromised at high levels of intoxication. This can lead to serious health risks, including loss of consciousness or alcohol poisoning. Therefore, while initial effects may seem mild, the most critical and life-threatening impacts occur as blood alcohol concentration increases.