Information Systems is a large umbrella referring to systems designed to create, store, manipulate, or disseminate information. An example of an information system is a pencil and a piece of paper. The two objects themselves are just tools, but together they create a system for writing (information).
Information technology falls under the information systems umbrella but has nothing to do with systems per say. IT deals with the technology involved in the systems themselves, e.g. an information system like wiki.answers.com contains many information technologies. Servers, server operating systems, web server software (IIS, Apache, et al.), and code written for the web server software (PHP, C#, VB, PERL, Ruby, et al.).
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