How far is it from Chattanooga TN to Biloxi MS?

It's about 460 miles from Chattanooga to Biloxi, depending on which route you take.

If you take this route, it is 460 miles.

1. Take I-24 WEST, from Chattanooga to I-59 SOUTH to BIRMINGHAM at EXIT 159 as it dips into GEORGIA.
2. Take I-59 SOUTH to I-65 SOUTH to MONTGOMERY, via I-459 SOUTH (EXIT 137 off I-59 in Alabama to get onto I-459 SOUTH towards MONTGOMERY ; EXIT 15 off I-459 to get onto I-65 SOUTH to MONTGOMERY).
3. Take I-65 SOUTH to I-10 WEST to Mississippi at EXIT 0 in Mobile.
4. Take I-10 WEST to I-110 SOUTH to BILOXI at EXIT 46A in MISSISSIPPI.
5. Take I-110 SOUTH to Biloxi.