E. coli cells are prokaryotic, meaning they lack a defined nucleus and membrane-bound organelles, while human cells are eukaryotic, possessing a nucleus and various organelles. Additionally, E. coli are generally smaller and simpler in structure, with a single circular chromosome, whereas human cells have multiple linear chromosomes. Furthermore, E. coli reproduce asexually through binary fission, while human cells undergo complex processes of mitosis and meiOSis for growth and reproduction.
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