How long a drive from Columbus oh to Beaufort SC?

The drive from Columbus, OH, to Beaufort, SC, typically takes around 8 to 10 hours, covering approximately 550 to 600 miles, depending on the specific route taken. The most common route is via I-77 S and I-95 S. Traffic conditions and stops can affect the overall travel time, so it's wise to check for real-time updates before heading out.