What is maternal-fetal blood group incompatibility associated with?

Maternal-fetal blood group incompatibility, most commonly associated with Rh incompatibility, occurs when an Rh-negative mother carries an Rh-positive fetus. This can lead to the mother’s immune system producing antibodies against the fetal Rh-positive red blood cells, potentially causing hemolytic disease of the newborn (HDN). HDN can result in anemia, jaundice, and in severe cases, heart failure or stillbirth. Prevention typically involves administering Rh immunoglobulin (RhIg) during pregnancy and after delivery.