What antipsychotics cross the blood brain barrier?

Most antipsychotics are designed to cross the blood-brain barrier to exert their effects on the central nervous system. This includes both first-generation antipsychotics, like haloperidol and chlorpromazine, and second-generation antipsychotics, such as risperidone, olanzapine, and quetiapine. The ability to cross the blood-brain barrier is crucial for their therapeutic efficacy in treating conditions like schizophrenia and Bipolar disorder. However, the extent of penetration can vary based on the drug's chemical properties and its affinity for specific receptors in the brain.