How do you get a guinea pig to let you pick it up?

For the first day you get your guinea pig you should leave him alone for 1 - 3 days.

When those 3 days are up you start talking gently to him so he can get use to you even if it includes talking to your self ( and still you do not pick up your piggy). When all of these days are up then the time is right to start picking up him or her,but you still have to do everything since the first day.Every time you pick him up make sure that you give him a couple of treats.

And last of all make sure he see's you refilling his water or food so he realizes that you are a caregiver.