The process of making bone is called ossification or osteogenesis. This process involves the transformation of cartilage or fibrous tissue into bone tissue, primarily through the activity of cells called osteoblasts, which synthesize bone matrix and promote mineralization. Ossification occurs in two main ways: intramembranous ossification, which forms flat bones like the skull, and endochondral ossification, which forms long bones like those in the arms and legs.
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