What was the most destructive force to the native American population during this period of time?

The most destructive force to the Native American population during this period was the combination of European colonization and the introduction of Infectious Diseases. Diseases such as smallpox, influenza, and measles decimated indigenous populations, who had no immunity to these foreign illnesses. Additionally, violent conflicts resulting from land encroachment, forced removals, and broken treaties further contributed to their decline. Together, these factors led to significant population loss and cultural disruption among Native American communities.