What are 3 major reasons for the conflict between the Spanish and the Indigenous people?

The conflict between the Spanish and Indigenous people largely stemmed from the Spanish quest for wealth, particularly through the extraction of gold and silver, leading to the exploitation and enslavement of Indigenous populations. Cultural and religious imposition, as the Spanish sought to convert Indigenous people to Christianity, further fueled tensions. Additionally, land disputes arose as the Spanish colonized territories, disrupting Indigenous ways of life and leading to violent confrontations.