What were the conflicts between farmers and cattle ranchers about?

I know after the invention of barbed wire in 1874 by Joseph Glidden the farmers and homesteaders fenced off their land, which closed off the open range and prevented any further cattle drives. I think it was always sort of a land issue, farmers wanted it to farm and ranchers wanted it to raise and drive cattle. It could also be a water issue, since in most areas water was kind of scarce.