What are the differences between ESI and MALDI in terms of ionization techniques used in mass spectrometry?

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1151191

2026-07-08 21:45

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Electrospray ionization (ESI) and matrix-assisted laser desorption/ionization (MALDI) are two ionization techniques used in mass spectrometry. ESI involves the use of an electric field to create charged droplets from a liquid sample, while MALDI uses a laser to vaporize and ionize solid samples mixed with a matrix compound. ESI is typically used for analyzing larger molecules like proteins, while MALDI is more suitable for analyzing smaller molecules like peptides and small organic compounds.

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