I think it depends on what the liquid is and how sensitive your skin is. For the high majority, water won't make you itch, but battery acid (like the kind that goes into car, bike, boat, etc. batteries) can make you itch and turn the skin red. But, once again, it depends on how sensitive your skin is, and how long the liquid is up there.
Also, don't forget, it depends on what the liquid actually is. (Chemically)
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