According to the laws of Bergonie and Tribondeau, the most radiOSensitive cells are those that are highly mitotic (rapidly dividing), undifferentiated, and have a long lifespan. This includes cells such as stem cells, germ cells, and certain types of epithelial cells. In contrast, mature and differentiated cells, which are less proliferative, tend to be more radioresistant. This principle is crucial in understanding the effects of radiation on different tissues in the body.
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