Do you use handicaps in the skins golf game?

One way is just like in a stroke play tournament.

Lets say your foursome has a 5, 7, 10, 11 handicappers. Then you would adjust the 7 by giving 1 stroke on the 2 hardest holes, 5 hardest holes for the 10 and so forth. However, you must all tee from the same tee box.