How many miles is it to Florida to route 66?

The distance from Florida to Route 66 varies depending on the starting point in Florida and the specific segment of Route 66 you are referencing. Generally, the distance can range from about 800 to over 1,500 miles. For example, driving from Miami to the closest point on Route 66 in Missouri is approximately 1,000 miles. Always check a map for precise routes and distances.