How can I travel by bus from Toronto to Buffalo?

Take I-290 to Peace Bridge. Once in Canada take QEW East to Toronto. If you are heading to the northern Toronto suburbs or to the Pearson Airport follow the 407 toll way east after you go over the bridge in Hamilton off of the QEW. Or take I-190 North to Lewiston Bridge then to the 405 to Qew east to 403 to 401 down to Toronto.