To replace the spark plugs in a 2001 Ford F-150 with a 4.6L engine, first, ensure the engine is cool and disconnect the negative battery terminal. Remove the ignition coil by unbolting it and disconnecting the electrical connector. Then, use a spark plug socket and ratchet to carefully unscrew the old spark plugs. Install the new plugs by hand to avoid cross-threading, then reattach the ignition coils and reconnect the battery.
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