Can you replace vanilla extract with orange juice?

There are two different possible routes here.

You can certainly substitute orange extract with other flavored extracts if the substitution is because of a taste preference.

However, if you still want the orange flavor, there are a couple main options:

1. Using a combination of orange zest and Orange Juice, you can still get the flavor to be infused into the dish.

2. There are also oils available that are safe for ingesting.

Either one of these should be tested before serving just to make sure that you are happy with the outcome as using these substitutions require different measurements (usually to taste preferences.)