Physical dependence occurs when a person's body adapts to a substance, leading to withdrawal symptoms when the substance is not taken; for example, someone who regularly uses opioids may experience nausea and tremors if they suddenly stop. In contrast, psychological dependence involves emotional or mental reliance on a substance to cope with stress or anxiety, such as a person who feels they need alcohol to socialize or relax. While physical dependence is marked by biological changes, psychological dependence focuses on the emotional connection to the substance.
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