What were some of the negative outcomes of journeys to the new world in the Renaissance?

During the Renaissance, journeys to the New World often resulted in significant negative outcomes, including the devastating impact on Indigenous populations through violence, disease, and forced labor. European colonizers brought Infectious Diseases like smallpox, which decimated Native American communities lacking immunity. Additionally, the exploitation of resources and the establishment of plantations led to ecological degradation and the displacement of local populations. These consequences contributed to long-lasting social and cultural disruptions in the Americas.