What disease leads to progressive muscle atrophy?

Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, leads to progressive muscle atrophy. It is a neurodegenerative disorder that affects motor neurons in the brain and spinal cord, resulting in muscle weakness, loss of coordination, and eventual atrophy as the motor neurons degenerate and die. This progressive decline in muscle function can significantly impact daily activities and quality of life.