To calculate the number of different 4-digit combinations that can be made using numbers 0 through 9, we use the concept of permutations. Since repetition is allowed, we use the formula for permutations with repetition, which is n^r, where n is the number of options for each digit (10 in this case) and r is the number of digits (4 in this case). Therefore, the number of different 4-digit combinations that can be made using numbers 0 through 9 is 10^4, which equals 10,000 combinations.
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