All homes produced use a variety of lumber dimensions including 2x4s and 2x6s. Each serves a different purpose in the construction. Typically, joists in the floors and ceilings are 2x6s, as they are a much stronger beam member compared to a 2x4 at a given span length for any simply supported beam. Roof rafters are typically the same dimensions as joists, as the rafters must directly support snow, wind, rain, live, and dead loads.
2x4s are typically used in walls and other miscellaneous construction within the home. In many homes 2x4s make up the exterior walls as well, as they are used to frameout doorways and Windows, however some homes may have exterior walls made from 2x6s. The benefits of 2x6s exterior walls lies in the amount of insulation which can be placed in the wall, which aids in the reduction of heat lost to the outside environment, they do cost more though.
Open your front door and measure the width of your jamb. Subtract 1/2 inch for drywall and 1/2 inch for outside sheathing. Then see what your width is.
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