What do you perceive is the basic problem in AMBER?

The basic problem in AMBER (Assisted Model Building with Energy Refinement) lies in its computational complexity and the accuracy of its force fields. While AMBER is effective for simulating biomolecular systems, it can struggle with the precise representation of certain interactions, particularly in heterogeneous environments or when dealing with large systems. Additionally, the software's user interface and documentation may pose challenges for new users, making it less accessible for some researchers.