To change the thermostat on a 2006 Honda Odyssey, first, ensure the engine is cool and disconnect the negative battery cable. Drain the coolant from the radiator, then remove the upper radiator hose and the thermostat housing to access the thermostat. Replace the old thermostat with the new one, ensuring the gasket is properly seated, and then reassemble by reversing the steps. Finally, refill the coolant and check for leaks before starting the engine.
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