An unintended consequence of Hernando de Soto's expedition was the introduction of European diseases to Indigenous populations in the southeastern United States. These diseases, such as smallpox and influenza, decimated Native American communities, who had no immunity to them. Additionally, the expedition led to increased violence and disruption of Indigenous societies as de Soto's forces sought resources and encounters with local tribes. This ultimately contributed to significant social and cultural upheaval in the region.
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