When addressing a senator and their spouse in a letter, begin with "The Honorable [Senator's Full Name]" for the senator, followed by "and Mrs. [Spouse's Last Name]" if you know their name. If the spouse's name is not known, you can simply use "and Mr. [Spouse's Last Name]" or "and Family." For example, "The Honorable John Smith and Mrs. Smith." Make sure to use formal titles and maintain respect throughout the letter.
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