The spread of disease had a devastating impact on Native American populations, leading to significant mortality rates due to lack of immunity to European illnesses such as smallpox and influenza. In contrast, while European populations also experienced outbreaks, their overall resilience to these diseases meant that they were less affected in comparison. This demographic collapse among Native Americans facilitated European colonization and conquest, altering the social and cultural landscapes of the Americas. Ultimately, the spread of disease exacerbated the power imbalance between the two groups, enabling European settlers to dominate the continent.
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